CURCUMINE REDUCES THE GROWTH OF COLORECTAL LIVER IMPLANTS IN RATS

Abstract INTRODUCTION Some plant-based antioxidants, such as curcumin, have shown anti-tumour properties against breast carcinomas and gliomas. The aim of this piece work is to assess the effect curcumin on CC531 colorectal cancer cells, both in vitro vivo. MATERIAL AND METHODS On cultures, cell viability was analysed, well migration capacity (wound healing test), 24, 48 72 hours after treatment with (15, 20, 25 or 30 µM). Additionally, WAG/RijHsd rats bearing CC531-induced liver implants, total individual lobe tumour volume quantified untreated curcumin-treated animals (200 mg/kg/day, oral). Furthermore, serum enzyme measurements (GOT, GPT, glucose, bilirubin, etc.) were carried out possible effects function. ANOVA t tests used analyse curcumine treatment. RESULTS In studies showed curcumin's greatest 48h application, when all tested doses reduced proliferation by more than 30% (0.443±0.06 vs. 0.319±0.04, 0.302±0.06, 0.274±0.06 0.243±0.03, respectively; p < 0.0001). At hours, highest (25 µM) less 50%. Wound test also that inhibits capacity. vivo, 5.6 fold implants (7.98±1.45 vs 1.41±1.33; 0.0001); however, healthy tissue higher (10.91±1.01 8.80±1.06; > 0.01). CONCLUSIONS Curcumin has an from cancer, experimental model.